Research Articles

  1. P. Gan, J. Pitzen, P. Qu, S. A. Snyder. Total Synthesis of the Caged Indole Alkaloid Arboridinine Enabled by aza-Prins and Metal-Mediated Cyclizations
    J. Am. Chem. Soc. 2018,140, 919.

  2. Q. Ye, P. Qu, S. A. Snyder. Total Syntheses of Scaparvins B, C, and D Enabled by a Key C–H Functionalization
    J. Am. Chem. Soc. 2017,139, 18428.

  3. F. Schevenels, M. Shen, S. A. Snyder. Isolable and Readily Handled Halophosphonium Pre-reagents for Hydro- and Deuteriohalogenation
    J. Am. Chem. Soc. 2017,139, 6329.

  4. P. Hu, S. A. Snyder. Enantiospecific Total Synthesis of the Highly Strained (−)-Presilphiperfolan-8-ol via a Pd-Catalyzed Tandem Cyclization
    J. Am. Chem. Soc. 2017,139, 5007.

  5. F. T. Schevenels, M. Shen, S. A. Snyder. Alkyldisulfanium Salts: Isolable, Electrophilic Sulfur Reagents Competent for Polyene Cyclizations
    Org.Lett. 2017,19, 2.

  6. M. W. Smith, Z. Zhou, A. X. Gao, T. Shimbayashi, S. A. Snyder. A 7-Step Formal Asymmetric Total Synthesis of Strictamine via an Asymmetric Propargylation and Metal-Mediated Cyclization.

    Org.Lett. 2017, 19, 1004.
  7. M. Shen, M. Kretschmer, Z. G. Brill, S. A. Snyder. Strategies for the Total Synthesis of Diverse Bromo-Chamigrenes
    Org.Lett. 2016, 18, 5018.
  8. T. L. Rosenberry, P. K. Martin, A. J. Nix, S. A. Wildman, J. Cheung, S. A. Snyder, R. X. Tan. Hopeahainol A Binds Reversibly at the Acetylcholinesterase (AChE) Peripheral Site and Inhibits Enzyme Activity with a Novel Higher Order Concentration Dependence.
    Chemico-Biological Interactions 2016, 259, 78.
  9. A. X. Gao, T. Hamada, S. A. Snyder. The Enantioselective Total Synthesis of Exochomine.
    Angew. Chem. Int. Ed. 2016, 55, 10301.
  10. P. Gan, M. W. Smith, N. R. Braffman, S. A. Snyder,Pyrone Diels–Alder Routes to Indolines and Hydroindolines: Syntheses of Gracilamine, Mesembrine, and Δ7-Mesembrenone.
    Angew. Chem. Int. Ed. 2016, 55, 3625.
  11. J. M. Eagan, M. Hori, J. Wu, K. S. Kanyiva, S. A. Snyder. Synthesis and Application of Hajos-Parrish Ketone Isomers.
    Angew. Chem. Int. Ed. 2015, 54, 7842.
  12. A. M. Levinson, P. J. Milner, S. A. Snyder. Studies in selective 6-membered bromoether formation via bromonium and thiiranium-induced cyclizations.
    Tetrahedron Lett. 2015, 56, 3553.
  13. T. C. Sherwood, A. H. Trotta, S. A. Snyder. A Strategy for Complex Dimer Formation When Biomicry Fails: Synthesis of 10 Coccinellid Alkaloids.
    J. Am. Chem. Soc. 2014, 136, 9743.
    • Covered in Chemistry World magazine
  14. N. E. Wright, A. M. ElSohly, S. A. Snyder. Syntheses of Cyclotriveratrylene Analogues and Their Long Elusive Triketone Congeners.
    Org. Lett. 2014, 16, 3644.
  15. T. H. Jepsen, S. B. Thomas, Y. Lin, C. I. Stathakis, I. de Miguel, S. A. Snyder. Harnessing Quinone Methides: Total Synthesis of (+)-Vaticanol A.
    Angew. Chem. Int. Ed. 2014, 53, 6747.
    • Selected by the editors as a Hot Paper
    • Featured in Synfacts 2014, 784.
  16. N. E. Wright, S. A. Snyder. 9-Membered Carbocycle Formation: Development of Distinct Friedel–Crafts Cyclizations and Application to a Scalable Total Synthesis of (+)-Caraphenol A.
    Angew. Chem. Int. Ed. 2014, 53, 3409.
    • Featured in Synfacts 2014, 448.
  17. D. R. Griffith, L. Botta, T. G. St. Denis, S. A. Snyder. xplorations of Unique Caffeic Acid Derivatives: Total Syntheses of Rufescenolide, Yunnaneic Acids C and D, and Studies toward Yunnaneic Acids A and B.
    J. Org. Chem. 2014, 79, 88.
  18. M. W. Smith, S. A. Snyder. A Concise Synthesis of (+)-Scholarisine A Empowered by a Unique C-H Arylation.
    J. Am. Chem. Soc. 2013, 135, 12964.
    • One of the top 10 most downloaded papers for September 2013
    • Featured in Synfacts 2013, 1143; selected by editors as Synfact of the Month
    • Covered in Chemistry World magazine
  19. A. P. Brucks, D. S. Treitler, S.-A. Liu, S. A. Snyder. Explorations into the Potential of Chiral Sulfonium Reagent to Effect Asymmetric Halonium Additions to Isolated Alkenes.
    Synthesis 2013, 45, 1886.
    • Special invited submission in honor of Prof. Scott Denmark’s 60th birthday
  20. A. M. ElSohly, D. A. Wespe, T. J. Poore, S. A. Snyder. An Efficient Approach to the Securinega Alkaloids Empowered by Cooperative N-Heterocyclic Carbene/Lewis Acid Catalysis.
    Angew. Chem. Int. Ed. 2013, 52, 5789.
  21. D. S. Treitler, Z. Li, M. Krystal, M. Krystal, N. A. Meanwell, S. A. Snyder. Evaluation of HIV-1 inhibition by stereoisomers and analogues of the sesquiterpenoid hydroquinone peyssonol A.
    Bioorg. Med. Chem. Lett. 2013, 23, 2192.
  22. S. A. Snyder, A. P. Brucks, D. S. Treitler, I. Moga. Concise Synthetic Approaches for the Laurencia Family: Formal Total Syntheses of (±)-Laurefucin and (±)-E- and (±)-Z-Pinnatifidenyne.
    J. Am. Chem. Soc 2012, 134, 17714.
    • One of the top 5 most downloaded papers for October 2012
  23. S. A. Snyder, S. B. Thomas, A. C. Mayer, S. P. Breazzano. Total Syntheses of Hopeanol and Hopeahainol D Empowered by a Chiral Bronsted-acid Induced Pinacol Rearrangement.
    Angew. Chem. Int. Ed. 2012, 51, 4080.
    • Highlighted in Totally Synthetic column of Chemistry World magazine
  24. S. A. Snyder, Z. G. Brill. Structural Revision and Total Synthesis of Caraphenol B and C.
    Organic Letters 2011, 13, 5524.
  25. S. A. Snyder, D. S. Treitler, A. P. Brucks, W. I. Sattler. A General Strategy for the Stereocontrolled Preparation of Diverse 8- and 9-Membered Laurencia-type Bromoethers.
    J. Am. Chem. Soc. 2011, 133, 15898.
  26. S. A. Snyder, N. E. Wright, J. J. Pflueger, S. P. Breazzano. Total Syntheses of Heimiol A, Hopeahainol D, and Constrained Analogues.
    Angew. Chem. Int. Ed. 2011, 50, 8629.
  27. S. A. Snyder, A. Gollner, M. I. Chiriac. Regioselective Reactions for Programmable Resveratrol Oligomer Synthesis.
    Nature 2011, 474, 461.
    • Highlighted in Chemistry and Engineering News as News of the Week
    • Highlighted in Nature: Chemistry, Chemistry World, and several newspapers
  28. S. A. Snyder, D. A. Wespe, J. M. von Hof. A Concise, Stereocontrolled Total Synthesis of Rippertenol.
    J. Am. Chem. Soc. 2011, 133, 8850.
    • Highlighted in Totally Synthetic column of Chemistry World magazine
    • One of the Five Most Accessed Articles for May 2011
  29. S. A. Snyder, F. Kontes, A. M. ElSohly. Mechanistic Investigations of the Cyclocondensation Step of the Knorr Pyrrole Synthesis.
    Heterocycles 2011, 84, 265.
    • Invited submission in honor of Prof. Albert Padwa’s 75th Birthday
  30. S. A. Snyder, F. Kontes. Synthetic Studies of Biomimetic Diels–Alder Processes towards the Helicterin Family of Natural Products.
    Isr. J. Chem. 2011, 51, 378.
    • Invited submission for a Special Issue on the Total Synthesis of Natural Products
  31. S. A. Snyder, D. S. Treitler. Synthesis of Et­2SBr•SbCl5Br and its use in Biomimetic Brominative Polyene Cyclizations.
    Organic Syntheses 2011, 88, 54.
  32. S. A. Snyder, A. M. ElSohly, F. Kontes. Synthetic and Theoretical Investigations of Myrmicarin Biosynthesis.
    Angew. Chem. Int. Ed 2010, 49, 9693.
  33. S. A. Snyder, D. S. Treitler, A. P. Brucks. Simple Reagents for Direct Halonium-induced Polyene Cyclizations.
    J. Am. Chem. Soc. 2010, 132, 14303.
  34. S. A. Snyder, T. C. Sherwood, A. G. Ross. Total Syntheses of Dalesconol A and B.
    Angew. Chem. Int. Ed. 2010, 49, 5146.
    • Selected by the editors as a Hot Paper
    • Highlighted in Chemistry and Engineering News in the July 5th, 2010 issue
    • Highlighted in Nature: Chemical Biology in the August 2010 issue
    • Reviewed in Angew. Chem. Int. Ed. 2011, 50, 4068.
  35. S. A. Snyder, D. S. Treitler, A. Schall. A Two-step Mimic for Direct, Asymmetric Bromonium- and Chloronium-induced Polyene Cyclizations.
    Tetrahedron 2010, 66, 4796.
    • Invited submission in honor of Prof. Brian M. Stoltz’ TYIA Award
  36. S. A. Snyder, D. S. Treitler. Et­2SBr•SbCl5Br: An Effective Reagent for Direct, Bromonium-induced Polyene Cyclizations.
    Angew. Chem. Int. Ed. 2009, 48, 7899.
    • Selected by the editors as a Hot Paper
  37. S. A. Snyder, Z. Tang, R. Gupta. Enantioselective Total Synthesis of (–)-Napyradiomycin A1 Via Asymmetric Chlorination of an Isolated Olefin.
    J. Am. Chem. Soc. 2009, 131, 5744.
    • One of the most accessed articles for April 2009
    • Featured in Synfacts 2009, 1186.
    • One of the 20 most accessed articles for 2009
  38. S. A. Snyder, S. P. Breazzano, A. G. Ross, Y. Lin, A. L. Zografos. Total Synthesis of Diverse Carbogenic Complexity within the Resveratrol Class from a Common Building Block.
    J. Am. Chem. Soc. 2009, 131, 1753.
    • Covered as a chapter in the textbook Classics in Total Synthesis III
    • Reviewed in Angew. Chem. Int. Ed. 2011, 50, 586.
    • Reviewed in Nature: Chemical Biology 2011, 7, 865.
  39. S. A. Snyder, F. Kontes. Explorations into Neolignan Biosynthesis: Total Synthesis of Helicterin B, Helisorin, and Helisterculin A from a Common Intermediate.
    J. Am. Chem. Soc. 2009, 131, 1745.
    • Reviewed in Tetrahedron 2010, 66, 2235.
    • Reviewed in Angew. Chem. Int. Ed. 2011, 50, 4068.
  40. S. A. Snyder, A. L. Zografos, Y. Lin. Total Synthesis of Resveratrol-based Natural Products: A Chemoselective Solution.
    Angew. Chem. Int. Ed. 2007, 46, 8186.
    • One of the most accessed articles for October 2007
    • Featured in Synfacts 2008, 219; selected by editors as “Synfact of the Month”
  41. S. A. Snyder, E. J. Corey. Concise Total Syntheses of Palominol, Dolabellatrienone, β-Araneosene, and Isoedunol Via an Enantioselective Diels-Alder Macrobicyclization.
    J. Am. Chem. Soc. 2006, 128, 740.
  42. S. A. Snyder, E. J. Corey. Regioselective Aldol Condensations of a Cholestanone-Derived Dialdehyde: New Twists on a Classic Reaction.
    Tetrahedron Lett. 2006, 47, 2083.
  43. K. C. Nicolaou, S. A. Snyder, D. A. Longbottom, A. Z. Nalbandian, X. Huang. New Uses for the Burgess Reagent in Chemical Synthesis: Methods for the Facile and Stereoselective Formation of Sulfamidates, Glycosylamines, and Sulfamides.
    Chem. Eur. J. 2004, 10, 5581.
  44. K. C. Nicolaou, J. Hao, M. V. Reddy, P. Bheema Rao, G. Rassias, S. A. Snyder, X. Huang, D. Y.-K. Chen, W. E. Brenzovich, N. Giuseppone, A. O'Brate, P. Giannakakou. Chemistry and Biology of Diazonamide A: Second Total Synthesis and Biological Investigations.
    J. Am. Chem. Soc. 2004, 126, 12897.
  45. K. C. Nicolaou, D. Y.-K. Chen, X. Huang, T. Ling, M. Bella, S. A. Snyder. Chemistry and Biology of Diazonamide A: First Total Synthesis and Confirmation of the True Structure.
    J. Am. Chem. Soc. 2004, 126, 12888.
  46. K. C. Nicolaou, S. A. Snyder, N. Giuseppone, X. Huang, M. Bella, M. V. Reddy, P. Bheema Rao, A. E. Koumbis, A. O'Brate, P. Giannakakou. Studies Toward Diazonamide A: Development of Hetero Pinacol Macrocyclization Cascade for the Construction of the Bis-Macrocyclic Framework of the Originally Proposed Structure
    J. Am. Chem. Soc. 2004, 126, 10174.
  47. K. C. Nicolaou, S. A. Snyder, X. Huang, K. B. Simonsen, A. E. Koumbis, A. Bigot. Studies Toward Diazonamide A: Initial Synthetic Forays Towards the Originally Proposed Structure.
    J. Am. Chem. Soc. 2004, 126, 10162.
  48. K. C. Nicolaou, S. A. Snyder, A. Z. Nalbandian, D. A. Longbottom. A New Method for the Stereoselective Synthesis of α- and β-Disposed Glycosylamines Using the Burgess Reagent.
    J. Am. Chem. Soc. 2004, 126, 6234.
  49. K. C. Nicolaou, P. Bheema Rao, J. Hao, M. V. Reddy, G. Rassias, X. Huang, D. Y.-K. Chen, S. A. Snyder. The Second Total Synthesis of Diazonamide A.
    Angew. Chem. Int. Ed. 2003, 42, 1753.
  50. K. C. Nicolaou, D. A. Longbottom, S. A. Snyder, A. Z. Nalbandian, X. Huang. A New Method for the Synthesis of Non-Symmetrical Sulfamides Using Burgess-Type Reagents.
    Angew. Chem. Int. Ed. 2002, 41, 3866.
  51. K. C. Nicolaou, M. Bella, D. Y.-K. Chen, X. Huang, T. Ling, S. A. Snyder. Total Synthesis of Diazonamide A.
    Angew. Chem. Int. Ed 2002, 41, 3495.
  52. K. C. Nicolaou, X. Huang, S. A. Snyder, P. Bheema Rao, M. Bella, M. V. Reddy. A Novel Regio- and Stereoselective Synthesis of Sulfamidates from 1,2-Diols Using Burgess and Related Reagents: A Facile Entry into β-Amino Alcohols.
    Angew. Chem. Int. Ed. 2002, 41, 834.
  53. K. C. Nicolaou, X. Huang, N. Giuseppone, P. Bheema Rao, M. Bella, M. V. Reddy, S. A. Snyder. Construction of the Complete Aromatic Core of Diazonamide A via a Novel Hetero Pinacol Macrocyclization Cascade Reaction.
    Angew. Chem. Int. Ed. 2001, 40, 4705.
  54. K. C. Nicolaou, S. A. Snyder, K. B. Simonsen, A. E. Koumbis. Model Studies Towards Diazonamide A: Synthesis of the Heterocyclic Core.
    Angew. Chem. Int. Ed. 2000, 39, 3473.
  55. K. C. Nicolaou, A. E. Koumbis, S. A. Snyder, K. B. Simonsen. Novel Reactions Initiated by Titanocene Methylidenes: Deoxygenation of Sulfoxides, N-Oxides, and Selenoxides.
    Angew. Chem. Int. Ed. 2000, 39, 2529.
  56. K. C. Nicolaou, S. A. Snyder, A. Bigot, J. A. Pfefferkorn. Solution and Solid Phase Synthesis of Functionalized 3-Arylbenzofurans via a Novel Cyclofragmentation Pathway.
    Angew. Chem. Int. Ed. 2000, 39, 1036.
  57. J. H. Markgraf, P. K. Sangani, R. J. Manalansan, S. A. Snyder, R. P. Thummel. Strained Heterocyclic Systems: The Menschutkin Reaction.
    J. Chem. Res. (S) 2000, 561.
  58. S. A. Snyder, D. A. Vosburg, M. G. Jarvis, J. H. Markgraf. Intramolecular Hetero Diels-Alder Routes to γ-Carboline Alkaloids.
    Tetrahedron 2000, 56, 5329.
  59. J. H. Markgraf, S. A. Snyder, D. A. Vosburg. A Concise Route to Isocanthin-6-one.
    Tetrahedron Lett. 1998, 39, 1111.
  60. F. Cao, R. Eckert, C. Elfgang, J. M. Nitsche, S. A. Snyder, D. F. Hulser, K. Willecke, B. J. Nicholson. A quantitative analysis of connexin-specific permeability differences of gap junctions expressed in HeLa transfectants and Xenopus oocytes.
    J. Cell Sci. 1998, 111, 31.

Review Articles

  1. S. A. Snyder, A. M. ElSohly, F. Kontes. Synthetic Approaches to Oligomeric Natural Products.
    Natural Products Reports 2011, 28, 897.
  2. S. A. Snyder, D. S. Treitler, A. P. Brucks. Halonium-induced Cyclization Reactions.
    Aldrichimica Acta. 2011, 44, 27.
  3. M. Welsch, S. A. Snyder, B. R. Stockwell. Privileged Scaffolds for Library Design and Drug Discovery.
    Curr. Opin. Chem. Biol. 2010, 14, 347.
  4. K. Pors, F. W. Goldberg, C. P. Leamon, A. C. Rigby, S. A. Snyder, R. A. Falconer. The Changing Landscape of Cancer Drug Discovery: A Challenge to the Medicinal Chemists of Tomorrow.
    Drug Discovery Today 2009, 14, 1045.
  5. K. C. Nicolaou, S. A. Snyder. Chasing Molecules That Were Never There: Misassigned Natural Products and the Role of Chemical Synthesis in Modern Structure Elucidation.
    Angew. Chem. Int. Ed. 2005, 44, 1012.
  6. K. C. Nicolaou, S. A. Snyder. The Essence of Total Synthesis.
    Proc. Nat. Acad. Sci. U.S.A. 2004, 101, 11929.
  7. K. C. Nicolaou, S. A. Snyder. Cascade Reactions in Total Synthesis: Recent Advances.
    L'Actualité Chimique 2003, 83.
  8. K. C. Nicolaou, T. Montagnon, S. A. Snyder. Tandem Reactions, Cascade Sequences, and Biomimetic Strategies in Total Synthesis.
    Chem. Commun. 2003, 551.
  9. K. C. Nicolaou, S. A. Snyder, T. Montagnon, G. E. Vassilikogiannakis. The Diels-Alder Reaction in Total Synthesis.
    Angew. Chem. Int. Ed. 2002, 41, 1668.

Book Chapters

  1. A. X. Gao, S. B. Thomas, S. A. Snyder.Pinacol and Semi-Pinacol Rearrangements in Total Synthesis.
    In Molecular Rearrangements for Organic Synthesis (Ed. C. Rojas), Wiley-VCH, 2014, in press.
  2. S. A. Snyder, A. M. Levinson. Polyene Cyclizations.
    In Comprehensive Organic Synthesis, Vol. II (Ed. G. Molander), Elsevier, 2014, in press.
  3. S. A. Snyder. Strategies for the Controlled Synthesis of Oligomeric Natural Products.
    In Recent Advances in Polyphenol Research, Vol. 3 (Ed. V. Cheynier, P. Sarni-Manchado, S. Quideau), Wiley-Blackwell, Chichester, 2012, 311-351.
  4. S. A. Snyder, A. P. Brucks. Asymmetric Halonium Addition to Olefins.
    In Asymmetric Synthesis – The Essentials, Vol. 2 (Ed. M. Christmann, S. Bräse), Wiley-VCH, Weinheim, 2012, 147-155.
  5. S. A. Snyder. Synthetic Approaches to the Resveratrol-based Family of Oligomeric Natural Products.
    In Biomimetic Organic Synthesis (Ed. E. Poupon and B. Nay), Wiley-VCH, Weinheim, 2011, pp. 695-721.
  6. K. C. Nicolaou, S. A. Snyder. The Olefin Metathesis Reaction in Complex Molecule Construction.
    In Handbook of Metathesis (Ed. R. H. Grubbs), Wiley-VCH, Weinheim, 2003, pp. 323-337.
  7. K. C. Nicolaou, H. J. Mitchell, S. A. Snyder. Synthesis of Complex Carbohydrates: Everninomicin 13,384-1.
    In Carbohydrate-based Drug Discovery (Ed. C.-H. Wong), Wiley-VCH, Weinheim, 2003, pp. 215-252.

Books

  1. K. C. Nicolaou, S. A. Snyder.
    Classics in Total Synthesis II: More Targets, Strategies, Methods, Wiley-VCH, Weinheim, 2003, p. 639.

Other Articles

  1. S. A. Snyder. Book review: Design and Strategy in Organic Synthesis. Angew. Chem. Int. Ed. 2014, 53, 3547.
  2. S. A. Snyder. Book review: Heterocycles in Natural Product Synthesis. Angew. Chem. Int. Ed. 2012, 51, 1307.
  3. S. A. Snyder. News and Views: Making Nematodes Nervous. Nature: Chemistry 2011, 3, 422.
  4. S. A. Snyder. Book Review: Classics in Stereoselective Synthesis. Chirality 2010, 22, 541.
  5. S. A. Snyder. Symmetrizing the Unsymmetrical. Nature 2010, 465, 560.
  6. S. A. Snyder. Arrow Pushing in Organic Chemistry. Angew. Chem. Int. Ed. 2009, 48, 640.
  7. S. A. Snyder. From Abyssomicin to Zaragozic Acid: Chemical Synthesis and Drug Innovation; Meeting review of the International Symposium on Chemistry, Biology, and Medicine held at Paphos, Cyprus, May 28-June 1, 2006. Angew. Chem. Int. Ed. 2006, 45, 4714.